Leveraging innate and adaptive mechanisms of anticancer immunity with IV heterologous vaccination

Time: 1:45 pm
day: Day Two

Details:

  • SNAPvaxTM is a self-assembling nanoparticle codelivering TLR-7/8a and cancer antigens
  • ChAdOx is an adenovirus that can be programmed to encode cancer antigens and has been demonstrated to be safe and effective for inducing T cell immunity in patients
  • Intravenous heterologous prime boost with SNAPvax and ChAdOx results in improved tumor clearance in preclinical animal models through two distinct mechanisms of action: (i) direct innate activation and reversal of suppressive populations within tumors, and (ii) induction of high magnitude T cells responses that mediate tumor killing.

Speakers: