Transcriptional Instability in Prostate Cancer as a Source of Shared Neoantigens
Time: 9:00 am
day: Day Two
- Identify a novel instability in cancer wherein cancer cells alter their transcriptional machinery and generate highly recurrent de novo RNA transcripts while maintaining a wild type genome status
- These aberrant transcription programs result in gene fusions and alternative RNA splicing that could generate long stretches of novel amino acid sequences.
- Our data supports the hypothesis that these aberrant transcription events generate an unanticipated and reproducible vulnerability that could be exploited for various therapeutic modalities.