Sargramostim as a Vaccine Adjuvant
Time: 9:30 am
day: Day Two
- GM-CSF induction of non-lymphoid tissue-resident dendritic cells (DCs) is
imperative for CD8+ T cell responses, leading to a history of GM-CSF use as an
adjuvant in numerous vaccines.
- Studies have reported both increased immune responses and immune
suppression, depending upon GM-CSF dosage and frequency.
- Concurrent strategies to suppress immunoregulatory cells may enhance GMCSF-
mediated DC induction as a strategy to boost adjuvanticity in emerging