Short, MHC-I Restricted Epitopes as Potent Cancer Vaccine Antigens when Admixed with a Particle-Inducing Adjuvant System

Time: 3:00 pm
day: Day One

Details:

  • Short MHC-I restricted peptides (9-mers) can induce strong, durable and
    functional antigen-specific CD8+ T cells when displayed on immunogenic
    liposomes
  • Short peptides particles can be used for immunization with higher-order
    multiplexing (ie 60 peptides) and for functional neoantigen discovery
  • Peptide sequences can be systematically interogated to find enhanced
    mimotopes for Class-I tumor-associated self-antigens

Speakers: