Identification and Validation of Neoantigens Resulting from Neo-open Reading Frames

Time: 11:15 am
day: Day Two


  •  Combination of the whole genome sequencing with short- and long-RNA sequencing unleashes the full potential of cancer neoantigen discovery
  • Showcasing how these technologies allow identification of neo-open reading frame peptides that represent long and completely foreign stretches of amino acids resulting from frame-shift mutations and genomic rearrangements in tumor tissue
  • Identifying and validating several neo-open reading frame peptides as neoantigens suitable for both off-the-shelf and personalized cancer vaccines