Vipul Bhargava

Vipul Bhargava

Company: Janssen R&D

Job title: Senior Principal Scientist


Transcriptional Instability in Prostate Cancer as a Source of Shared Neoantigens 9:00 am

Identify a novel instability in cancer wherein cancer cells alter their transcriptional machinery and generate highly recurrent de novo RNA transcripts while maintaining a wild type genome status These aberrant transcription programs result in gene fusions and alternative RNA splicing that could generate long stretches of novel amino acid sequences. Our data supports the hypothesis…Read more

day: Day Two

Ientification of Shared Neoantigens in Prostate Cancer 1:30 pm

Data to show critical understanding of the tumor microenvironment to determine response to immune checkpoint therapy in combination with cancer vaccines Identification of VISTA as a potent inhibitory checkpoint that is predominantly expressed on CD68+ macrophages on PDACs, suggesting that VISTA may be a relevant immunotherapy target for effective treatment of patients with pancreatic cancerRead more

day: Pre-Conference Focus Day

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